Dorota Łażewska Selected Research

Histamine H3 Receptors (Histamine H3 Receptor)

1/2021	Cyanobiphenyls: Novel H3 receptor ligands with cholinesterase and MAO B inhibitory activity as multitarget compounds for potential treatment of Alzheimer's disease.
1/2021	Ameliorating effects of histamine H3 receptor antagonist E177 on acute pentylenetetrazole-induced memory impairments in rats.
12/2020	Rational design of new multitarget histamine H3 receptor ligands as potential candidates for treatment of Alzheimer's disease.
11/2020	Corrigendum to "Search for new multi-target compounds against Alzheimer's disease among histamine H3 receptor ligands" [Eur. J. Med. Chem. 185 (2020) 111785].
6/2020	The Dual-Active Histamine H3 Receptor Antagonist and Acetylcholine Esterase Inhibitor E100 Alleviates Autistic-Like Behaviors and Oxidative Stress in Valproic Acid Induced Autism in Mice.
3/2020	Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats.
1/2020	Search for new multi-target compounds against Alzheimer's disease among histamine H3 receptor ligands.
1/2020	Simultaneous Blockade of Histamine H3 Receptors and Inhibition of Acetylcholine Esterase Alleviate Autistic-Like Behaviors in BTBR T+ tf/J Mouse Model of Autism.
11/2019	The Neuroprotective Effects of Histamine H3 Receptor Antagonist E177 on Pilocarpine-Induced Status Epilepticus in Rats.
10/2019	The dual-active histamine H3 receptor antagonist and acetylcholine esterase inhibitor E100 ameliorates stereotyped repetitive behavior and neuroinflammmation in sodium valproate induced autism in mice.

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Dorota Łażewska Research Topics

Disease

8	Epilepsy (Aura) 01/2021 - 01/2016
7	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 01/2016
4	Memory Disorders (Memory Loss) 06/2021 - 01/2017
4	Autistic Disorder (Autism) 06/2020 - 01/2018
3	Cognitive Dysfunction 03/2020 - 01/2018
2	Pain (Aches) 01/2022 - 01/2018
2	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2021 - 01/2019
2	Neuralgia (Stump Neuralgia) 12/2020 - 01/2018
2	Amnesia (Dissociative Amnesia) 12/2020 - 01/2019
2	Neuroblastoma 05/2020 - 01/2018
2	Narcolepsy 01/2020 - 10/2019
2	Schizophrenia (Dementia Praecox) 01/2020 - 10/2019
2	Inflammation (Inflammations) 01/2019 - 01/2017
2	Seizures (Absence Seizure) 10/2018 - 01/2018
2	Neoplasms (Cancer) 07/2018 - 01/2016
2	Edema (Dropsy) 01/2017 - 08/2014
1	Allergic Rhinitis 01/2021
1	Pruritus (Itching) 01/2021
1	Asthma (Bronchial Asthma) 01/2021
1	Atopic Dermatitis (Atopic Eczema) 01/2021
1	Colitis 01/2021
1	Body Weight (Weight, Body) 05/2020
1	Catalepsy 05/2020
1	Parkinson Disease (Parkinson's Disease) 05/2020
1	Central Nervous System Diseases (CNS Diseases) 12/2019
1	Obesity 12/2019
1	Status Epilepticus (Complex Partial Status Epilepticus) 11/2019
1	Neuroinflammatory Diseases 10/2019
1	Autism Spectrum Disorder 10/2019
1	Glaucoma 02/2019
1	Ocular Hypertension (Glaucoma, Suspect) 02/2019
1	Hepatocellular Carcinoma (Hepatoma) 01/2018
1	Brain Diseases (Brain Disorder) 01/2018
1	Hyperalgesia 01/2017
1	Peritonitis 01/2017
1	Alcoholism (Alcohol Abuse) 11/2015

Drug/Important Bio-Agent (IBA)

14	Histamine H3 Receptors (Histamine H3 Receptor)IBA 01/2021 - 01/2016
11	LigandsIBA 01/2022 - 01/2016
7	Histamine (Histamine Dihydrochloride)FDA Link 03/2020 - 01/2016
4	EsterasesIBA 06/2020 - 10/2019
4	Acetylcholine (Acetylcholine Chloride)FDA Link 06/2020 - 10/2019
3	Scopolamine (Hyoscine)FDA Link 06/2021 - 01/2017
3	Histamine H4 ReceptorsIBA 01/2021 - 01/2017
3	Dizocilpine Maleate (Dizocilpine)IBA 12/2020 - 01/2017
3	Analgesics (Analgesic Drugs)IBA 12/2020 - 01/2017
3	Valproic Acid (Depakote)FDA LinkGeneric 06/2020 - 01/2018
3	Anticonvulsants (Antiepileptic Drugs)IBA 03/2020 - 01/2018
3	Neurotransmitter Agents (Neurotransmitter)IBA 03/2020 - 01/2019
3	Pentylenetetrazole (Metrazol)IBA 03/2020 - 01/2018
3	CarrageenanIBA 01/2019 - 08/2014
3	imidazoleIBA 01/2019 - 01/2018
2	Monoamine Oxidase (MAO)IBA 06/2021 - 01/2021
2	Neuroprotective AgentsIBA 05/2020 - 11/2019
2	Pharmaceutical PreparationsIBA 12/2019 - 07/2018
2	Formaldehyde (Formol)FDA Link 01/2019 - 01/2018
2	Cytochrome P-450 CYP3AIBA 01/2018 - 08/2014
1	diphenyl (biphenyl)IBA 06/2021
1	ButyrylcholinesteraseIBA 06/2021
1	EnzymesIBA 06/2021
1	Cholinesterases (Cholinesterase)IBA 01/2021
1	Haloperidol (Haldol)FDA LinkGeneric 05/2020
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 05/2020
1	CatalaseIBA 03/2020
1	Glutathione (Reduced Glutathione)IBA 03/2020
1	gamma-Aminobutyric Acid (GABA)IBA 03/2020
1	Glutamic Acid (Glutamate)FDA Link 03/2020
1	Proto-Oncogene Proteins c-fos (FRAs)IBA 03/2020
1	Aminobutyrates (Aminobutyric Acid)IBA 03/2020
1	Malondialdehyde (Propanedial)IBA 03/2020
1	Superoxide DismutaseIBA 03/2020
1	TriazinesIBA 12/2019
1	HydantoinsIBA 12/2019
1	Serotonin ReceptorsIBA 12/2019
1	SulfonesIBA 12/2019
1	Anti-Anxiety Agents (Anxiolytics)IBA 12/2019
1	indoleIBA 12/2019
1	Pilocarpine (Ocusert)FDA LinkGeneric 11/2019
1	6- ((3- cyclobutyl- 2,3,4,5- tetrahydro- 1H- 3- benzazepin- 7- yl)oxy)- N- methyl- 3- pyridinecarboxamideIBA 02/2019
1	ciproxifanIBA 02/2019
1	carbomerIBA 02/2019
1	Morphine (MS Contin)FDA LinkGeneric 01/2018
1	Donepezil (Aricept)FDA LinkGeneric 01/2017
1	zolantidineIBA 01/2017
1	Pyrilamine (Mepyramine)FDA Link 01/2017
1	ZymosanIBA 01/2017
1	pitolisantIBA 01/2017
1	Ethanol (Ethyl Alcohol)IBA 11/2015

Therapy/Procedure

4	Therapeutics 01/2022 - 01/2018
1	Immunotherapy 07/2018
1	Analgesia 01/2018